魏育明

	姓 名：魏育明
	学 历：博士	职 称：教授，博士导师
	职 务：所长	电 话：86-028-86290909
	电 箱：ymwei@sicau.edu.cn	传 真：86-028-82650350

主要研究方向：

1. 小麦重要性状基因发掘及其分子标记

小麦产量、品质和抗性等性状往往是多基因控制的复杂性状，也是小麦遗传改良的重要目标性状。课题组对高产、优质、抗病或抗逆等优异基因的遗传材料进行筛选鉴定，构建遗传分析群体，对这些重要性状基因进行分子标记，并将获得的与重要性状基因连锁的分子标记应用于小麦分子标记辅助育种，进行小麦新材料创制与新品种选育。本研究受到国家重点实验室“生物育种”专项和四川省农业农村厅麦类作物创新团队项目资助。

2. 点突变导致小麦Dy10亚基翻译后剪切的分子机制及其加工品质效应

高分子量谷蛋白（HMW-GS）决定小麦面团的弹性，对加工品质起重要作用。Dy10亚基与面筋强度密切相关，是公认的优质亚基。我们利用化学诱变创制了一份蜀麦482 Dy10亚基突变体，发现其Dy10亚基C-末端非重复区一个碱基的变异导致部分Dy10蛋白在合成过程中被酶切，从而形成一种新型Dy10亚基。本项目拟在前期工作基础上，综合利用酵母杂交、GST pull-down和质谱检测、体外表达纯化及蛋白复性技术、亚细胞共定位技术、转基因、双分子荧光互补实验等技术，鉴定出负责翻译后切割突变体Dy10亚基的酶及其基因，明确其切割突变体Dy10亚基的分子机制；通过构建比较野生型和突变体的加工品质参数，评价突变体Dy10亚基的加工品质效应。在此基础上，明确点突变导致小麦高分子量谷蛋白Dy10亚基翻译后剪切的分子机制及其加工品质效应。本研究受国家自然科学基金资助。

3. 绿色高效小麦重大新品种培育

针对四川小麦绿色高效生产中的突出短板，着力解决综合抗病耐逆（尤其是赤霉病和穗发芽）能力差、肥料利用效率低和重金属积累等制约绿色高效生产的关键问题。开展抗病、耐逆、水肥高效利用等绿色高效相关性状的精准鉴定，发掘小麦及其外源野生物种优良基因资源，建立小麦分子染色体育种技术体系，选育绿色高效小麦重大新品种，研发新品种配套的高产绿色高效栽培技术体系和推广示范新机制，实现重大新品种大面积示范推广，充分发挥品种增产增收潜力，大幅提高种粮效益，保障粮食安全。本研究受到四川省生物育种重大专项资助。

近期论文：

1. Yuanying Peng, Honghai Yan, Laichun Guo, Cao Deng, Chunlong Wang, Yubo Wang, Lipeng Kang, Pingping Zhou, Kaiquan Yu, Xiaolong Dong, Xiaomeng Liu, Zongyi Sun, Yun Peng, Jun Zhao, Di Deng, Yinghong Xu, Ying Li, Qiantao Jiang, Yan Li, Liming Wei, Jirui Wang, Jian Ma, Ming Hao, Wei Li, Houyang Kang, Zhengsong Peng, Dengcai Liu, Jizeng Jia, Youliang Zheng, Tao Ma, Yuming Wei*, Fei Lu*, Changzhong Ren*. Reference genome assemblies reveal the origin and evolution of allohexaploid oat. Nature Genetics, 2022, 54: 1248-1258

2. Xu Qiang, Hu Su, Jin Minxia, Xu Yangjie, Jiang Qiantao, Ma Jian, Zhang Yazhou, Qi Pengfei, Chen Guoyue, Jiang Yunfeng, Zheng Youliang, Wei Yuming*. The N-terminus of a Fusarium graminearum-secreted protein enhances broad-spectrum disease resistance in plants. Molecular Plant Pathology, 2022, DOI 10.1111/mpp.13262

3. Guo Xiaojiang, Fu YX, Lee Y-RJ, Chern M, Li Maolian, Cheng Mengping, Dong Hhuixue, Yuan Zongwei, Gui LX, Yin JJ, Qing H, Zhang CB, Pu ZhiEn, Liu Yujiao, Li Weitao, Li Wei, Qi Pengfei, Chen Guoyue, Jiang Qiantao, Ma Jian, Chen Xuewei, Wei Yuming, Zheng Youliang, Wu YR, Liu B, Wang Jirui. The PGS1 basic helix-loop-helix (bHLH) protein regulates Fl3 to impact seed growth and grain yield in cereals. Plant Biotechnology Journal, 2022, 20: 1311-1326

4. Guo Zhenru, Chen Qing, Zhu Jing, Wang Yan, Li Yang, Li Qingcheng, Zhao Kan, Li Yue, Tang Rrui, Shi Xiaoli, Tan Kenan, Kong Li, Jiang Yunfeng, Jiang Qiantao, Wang Jirui, Chen Guoyue, Wei Yuming, Zheng Youliang, Qi Pengfei. The Qc5 allele increases wheat bread-making quality by regulating SPA and SPR. International Journal of Molecular Sciences, 2022, 23: 7581

5. Guo Zhenru, Chen Qing, Zhu Jing, Wang Yan, Li Yang, Li Qingcheng, Zhao Kan, Li Yue, Tang Rrui, Shi Xiaoli, Tan Kenan, Kong Li, Jiang Yunfeng, Jiang Qiantao, Wang Jirui, Chen Guoyue, Wei Yuming, Zheng Youliang, Qi Pengfei. The Qc5 allele increases wheat bread-making quality by regulating SPA and SPR. International Journal of Molecular Sciences, 2022, 23: 7581

6. Pu Zhien; Pei Ying; Yang Jian; Ma Jian; Li Wei; Liu Dengcai; Wang Jirui; Wei Yuming; Zheng Youliang. Identification and validation of novel loci associated with wheat quality through genome-wide association study. Journal of Integrative Agriculture，2022, 21(11): 3131-3147

7. Chen Qing, Guo Zhenru, Shi Xiaoli, Wei Meiqiao, Fan Yazhen, Zhu Jing, Zheng Ting, Wang Yan, Kong Li, Deng Mei, Cao Xinyou, Wang Jirui, Wei Yuming, Jiang Qiantao, Jiang Yunfeng, Chen Guoyue, Zheng Youliang, Qi Pengfei. Increasing the grain yield and grain protein content of common wheat (Triticum aestivum) by introducing missense mutations in the Q gene. International Journal of Molecular Sciences, 2022, 23: 10772

8. Lang Jing, Fu YX, Zhou Yong, Cheng Mengping, Deng Mei, Li Maolian, Zhu TT, Yang Jian, Guo Xiaojiang, Gui LX, Li LC, Chen Zhongxu, Yi YJ, Zhang Lianquan, Hao Ming, Huang Lin, Tan C, Chen Guoyue, Jiang Qiantao, Qi Pengfei, Pu Zhien, Ma Jian, Liu Zhehou, Liu YJ, Luo Mingcheng, Wei Yuming, Zheng Youliang, Wu YR, Liu Dengcai, Wang Jirui. Myb10-D confers PHS-3D resistance to pre-harvest sprouting by regulating NCED in ABA biosynthesis pathway of wheat. New Phytologist, 2021, 230: 1940-1952

9. Pu Zhien; Wei Guanghui; Liu Zehou; Chen Li; Guo Han; Li Yang; Dai Shoufen; Wang Jirui; Li Wei; Jiang Qiantao; Wei Yuming; Zheng Youliang. Selenium and anthocyanins share the same transcription factors R2R3MYB and bHLH in wheat. Food Chemistry, 2021, 356: 129699

10. Chen Qing, Lei Lu, Liu Caihong, Zhang Yazhou, Xu Qiang, Zhu Jing, Guo Zhenru, Wang Yan, Li Qingcheng, Li Yang, Kong Li, Jiang Yunfeng, Lan Xiujin, Wang Jirui, Jiang Qiantao, Chen Guoyue, Ma Jian, Wei Yuming, Zheng Youliang, Qi Pengfei. Major facilitator superfamily transporter gene FgMFS1 is essential for Fusarium graminearum to deal with salicylic acid stress and for its pathogenicity towards wheat. International Journal of Molecular Sciences, 2021, 22: 8497

11. Yang Tu, Hang Liu, Jiajun Liu, Huaping Tang, Yang Mu, Mei Deng, Qiantao Jiang, Yaxi Liu, Guoyue Chen, Jirui Wang, Pengfei Qi, Zhien Pu, Guangdeng Chen, Yuanying Peng, Yunfeng Jiang, Qiang Xu, Houyang Kang, Xiujin Lan, Yuming Wei, Youliang Zheng, Jian Ma. QTL mapping and validation of bread wheat flag leaf morphology across multiple environments in different genetic backgrounds. Theoretical and Applied Genetics, 2021, 134: 261-278

12. Wang Yan, Chen Qing, Li Yang, Guo Zhenru, Liu Caihong, Wan Yongfang, Hawkesford Malcolm, Zhu Jing, Wu Wang, Wei Meiqiao, Zhao Kan, Jiang Yunfeng, Zhang Yazhou, Xu Qiang, Kong Li, Pu Zhien, Deng Mei, Jiang Qiantao, Lan Xiujin, Wang Jirui, Chen Guoyue, Ma Jian, Zheng Youliang, Wei Yuming, Qi Pengfei. Post-translational cleavage of HMW-GS Dy10 allele improves the cookie-making quality in common wheat (Triticum aestivum). Molecular Breeding, 2021, 41: 49

13. Ma J*, Tu Y, Zhu J, Luo W, Liu H, Li C, Li S, Liu J, Ding P, Habib A, Mu Y, Tang H, Liu Y, Jiang Q, Chen G, Wang J, Li W, Pu Z, Zheng Y, Wei Y, Kang H, Chen G, Lan X. Flag leaf size and posture of bread wheat: genetic dissection, QTL validation and their relationships with yield-related traits. Theoretical and Applied Genetics, 2020, 133: 297-315

14. Yang Q, Zhong X, Li Q, Lan J, Tang H, Qi P, Ma J, Wang J, Chen G, Pu Z, Li L, Lan X, Deng M, Harwood W, Li Z, Wei YM, Zheng YL, Jiang Q*. Mutation of the D-hordein gene by RNA-guided Cas9 targeted editing reducing the grain size and changing grain compositions in barley, Food Chemistry, 2020,125892

15. Li T, Ma J, Zou Y, Chen G, Ding P-Y, Zhang H, Yang C-C, Mu Y, Tang H, Liu Y, Jiang Q, Chen G-Y, Qi P-F, Wei Y-M, Zheng Y, Lan X-J. Quantitative trait loci for seeding root traits and the relationships between root and agronomic traits in common wheat. Genome, 2020, 63: 27-36

16. Jiang Y, Chen Q, Wang Y, Guo Z, Xu B, Zhu J, Zhang Y, Gong X, Luo C, Wu W, Liu C, Kong L, Deng M, Jiang Q, Lan X, Wang J, Chen G, Zheng Y^*, Wei YM, Qi P*. Re-acquisition of the brittle rachis trait via a transposon insertion in domestication gene Q during wheat de-domestication. New Phytologist, 2019, 224: 961-973

17. Lin Y, Yi X, Tang S, Chen W, Wu FK, Yang XL, Jiang XJ, Shi HR, Ma J, Chen GD, Chen GY, Zheng YL, Wei YM*, Liu YX*. Dissection of Phenotypic and Genetic Variation of Drought Related Traits in Diverse Chinese Wheat Landraces. The Plant Genome, 2019, 12 (3):1-14.

18. Ma J,*, Ding P, Liu J, Li T, Zou Y, Habib A, Mu Y, Tang H, Jiang Q, Liu Y, Chen G, Wang J, Deng M, Qi P, Li W, Pu Z, Zheng Y, Wei Y, Lan X*. Identification and validation of a major and stably expressed QTL for spikelet number per spike in bread wheat. Theoretical and Applied Genetics , 2019, 132: 3155–3167

19. Luo M, Ding JJ, Li Y, Tang HP, Qi PF, Ma J, Wang JR, Chen GY, Pu ZE, Li W, Li ZY, W Harwood, Lan XJ, Deng M, Lu ZX, Wei YM, Zheng YL, Jiang QT*. A single-base change at a splice site in Wx-A1 caused incorrect RNA splicing and gene inactivation in a wheat EMS mutant line. Theoretical and Applied Genetics, 2019, 132: 2097-2109

20. Ma J, Qin N, Cai B, Chen G, Ding P, Zhang H, Yang C, Huang L, Mu Y, Tang H, Liu Y, Wang J, Qi P, Jiang Q, Zheng YL, Liu C, Lan X, Wei YM*. Identification and validation of a novel major QTL for all-stage stripe rust resistance on 1BL in the winter wheat line 20828. Theoretical and Applied Genetics, 2019, 132: 1363-1373

21. Luo M, Ding JJ, Li Y, Tang HP, Qi PF, Ma J, Wang JR, Chen GY, Pu ZE, Li W, Li ZY, Harwood W, Lan XJ, Deng M, Lu ZX, Wei YM, Zheng YL, Jiang QT*. A single-base change at a splice site in Wx-A1 caused incorrect RNA splicing and gene inactivation in a wheat EMS mutant line. Theoretical and Applied Genetics, 2019, 132: 2097–2109

22. Jiang YF, Habib A, Zheng Z, Zhou MX, Wei YM, Zheng YL, Liu CJ*. Development of tightly linked markers and identification of candidate genes for Fusarium crown rot resistance in barley by exploiting a near isogenic line derived population. Theoretical and Applied Genetics, 2019, 132: 217–225

23. Hao M, Zhang LQ, Zhao LB, Dai SF, Li AL, Yang WY, Xie DE, Li QC, Ning SZ, Yan ZH, Wu BH, Lan XJ, Yuan ZW, Huang L, Wang JR, Zheng K, Chen WS, Yu M, Chen XJ, Chen MP, Wei YM, Zhang HG, Kishii M , Hawkesford MJ, Mao L, Zheng YL, Liu DC*. A breeding strategy targeting the secondary gene pool of bread wheat: introgression from a synthetic hexaploid wheat. Theoretical and Applied Genetics, 2019, 132: 2285-2294

24. Wang ZQ, Shi HR, Yu SF, Zhou WL, Li J, Liu SH, Deng M, Ma J, Wei YM, Zheng YL, Liu YX*. Comprehensive transcriptomics, proteomics, and metabolomics analyses of the mechanisms regulating tiller production in low-tillering wheat. Theoretical and Applied Genetics, 2019, 132(8):2181-2193

25. Zhang YZ, Chen Q, Liu CH, Lei L, Li Y, Zhao K, Wei MQ, Guo ZR, Wang Y, Xu BJ, Jiang YF, Kong L, Liu YL, Lan XJ, Jiang QT, Ma J, Wang JR, Chen GY, Wei YM*, Zheng YL, Qi PF*. Fusarium graminearum FgCWM1 encodes a cell wall mannoprotein conferring sensitivity to salicylic acid and virulence to wheat. Toxins, 2019, 11: 628

26. Ye XL, Li J, Cheng YK, Yao FJ, Long L, Yu C, Wang YQ, Wu Y, Li J, Wang JR, Jiang QT, Li W, Ma J, Wei YM, Zheng YL, Chen GY*. Genome-wide association study of resistance to stripe rust (Puccinia striiformis f. sp. tritici) in Sichuan wheat. BMC Plant Biology, 2019, 19:147

27. Ye XL, Li J, Cheng YK, Yao FJ, Long L, Wang YQ, Wu Y, Li J, Wang JR, Jiang QT, Kang HY, Li W, Qi PF, Lan XJ, Ma J, Liu YX, Jiang YF, Wei YM, Chen XM, Liu, CJ, Zheng YL*, Chen GY*. Genome-wide association study reveals new loci for yield-related traits in Sichuan wheat germplasm under stripe rust stress. BMC Genomics, 2019, 20: 640

28. Qi PF*, Jiang YF, Guo ZR, Chen Q, Ouellet T, Zong LJ, Wei ZZ, Wang Y, Zhang YZ, Xu BJ, Kong L, Deng M, Wang JR, Chen GY, Jiang QT, Lan XJ, Li W, Wei YM, Zheng YL. Transcriptional reference map of hormone responses in wheat spikes. BMC Genomics, 2019, 20: 390

29. Fangjie Yao, Xuemei Zhang, Xueling Ye,Jian Li, Li Long, Can Yu, Jing Li, Yuqi Wang, Yu Wu, Jirui Wang, Qiantao Jiang, Wei Li, Jian Ma, Yuming Wei, Youliang Zheng, Guoyue Chen*. Characterization of molecular diversity and genome-wide association study of stripe rust resistance at the adult plant stage in Northern Chinese wheat landraces. BMC Genetics, 2019, 20:38

30. Ma J*, Zhang H, Li S, Zou Y, Li T, Liu J, Ding P, Mu Y, Tang H, Deng M, Liu Y, Jiang Q, Chen G, Kang H, Li W, Pu Z, Wei YM, Zheng Y, Lan X*. Identification of quantitative trait loci for kernel traits in a wheat cultivar Chuannong16. BMC Genetics, 2019, 20: 77

31. Qi PF, Zhang YZ, Liu CH, Chen Q, Guo ZR, Wang Y, Xu BJ, Jiang YF, Zheng T, Gong X, Luo CH, Wu W, Kong L, Deng M, Ma J, Lan XJ, Jiang QT, Wei YM*, Wang JR, Zheng YL. Functional Analysis of FgNahG Clarifies the Contribution of Salicylic Acid to Wheat (Triticum aestivum) Resistance against Fusarium Head Blight. Toxins, 2019: 11, 59

32. Liu H, Ma J*, Tu Y, Zhu J, Ding P, Liu J, Li T, Zou Y, Habib A, Mu Y, Tang H, Jiang QT, Liu Y, Chen G, Zheng YL, Wei YM, Lan XJ. Several stably expressed QTL for spike density of common wheat (Triticum aestivum) in multiple environments. Plant Breeding, 2019, 00: 1-11

33. Zhou Y, Chen ZX, Cheng MP, Chen J, Zhu TT, Wang R, Liu YX, Qi PF, Chen GY, Jiang QT, Wei YM, Luo MC, Nevo E, Allaby RG, Liu DC, Wang JR*, Dvorák J*, Zheng YL*. Uncovering the Dispersion History, Adaptive Evolution and Selection of Wheat in China. Plant Biotechnology Journal, 2018, 16: 280-291